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Protein Coding Gene : Dnali1 dynein, axonemal, light intermediate polypeptide 1
Primary Identifier  MGI:1922813 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  75563
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables dynein heavy chain binding activity. Involved in sperm flagellum assembly. Located in several cellular components, including ciliary base; filopodium; and sperm flagellum. Is expressed in several structures, including brain ventricle and choroid plexus; choroid invagination; ependyma; epithelium; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 83. Orthologous to human DNALI1 (dynein axonemal light intermediate chain 1).
PHENOTYPE: Mice homozygous for a null allele exhibit male infertility associated with asthenozoospermia, symmetrical longitudinal columns in sperm fibrous sheath, and hydrocephaly. [provided by MGI curators]
  • synonyms:
  • expressed sequence AW049135,
  • 1700023A09Rik,
  • Dnali1,
  • AW049135,
  • MGI:2140549,
  • RIKEN cDNA 1700023A09 gene,
  • dynein, axonemal, light intermediate polypeptide 1
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