| Primary Identifier | MGI:95816 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 14807 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables glutamate-gated calcium ion channel activity and ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway; glutamatergic synaptic transmission; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within regulation of membrane potential. Located in plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including central nervous system; chordamesoderm; future brain; gonad; and retina. Orthologous to human GRIK3 (glutamate ionotropic receptor kainate type subunit 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
