| Primary Identifier | MGI:1339755 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12986 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables granulocyte colony-stimulating factor binding activity. Acts upstream of or within neutrophil chemotaxis and regulation of myeloid cell differentiation. Predicted to be located in endocytic vesicle membrane and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including aorta-gonad-mesonephros; bone marrow; early conceptus; gut; and male reproductive gland or organ. Used to study hereditary neutrophilia. Human ortholog(s) of this gene implicated in hematologic cancer (multiple); hereditary neutrophilia; and severe congenital neutropenia (multiple). Orthologous to human CSF3R (colony stimulating factor 3 receptor). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced numbers of peripheral neutrophils, with fewer hematopoietic progenitors in bone marrow and impaired expansion and terminal differentiation of progenitors into granulocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
