Primary Identifier | MGI:1924100 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 76850 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables RNA binding activity. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and miRNA metabolic process. Located in P-body and nucleus. Part of RISC complex. Is expressed in several structures, including central nervous system; lung; sensory organ; tooth; and vibrissa. Orthologous to human AGO4 (argonaute RISC component 4). PHENOTYPE: Male mice homozygous for a null mutation display oligozoospermia, decreased testis weight, premature entry into meiosis and disruption of sex body formation. However both males and females are fertile. [provided by MGI curators] |