| Primary Identifier | MGI:2445153 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 269582 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in activation of protein kinase activity; mitotic G2/M transition checkpoint; and peptidyl-serine phosphorylation. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; endocrine gland; genitourinary system; and immune system. Orthologous to human CLSPN (claspin). PHENOTYPE: Homozygous null mice show complete embryonic lethality during organogenesis. Heterozygous null mice exhibit reduced female fertility, develop lymphoid hyperplasia as they age, and show increased susceptibility to non-alcoholic fatty liver disease, and increased liver damage and tumorigenesis in the DEN model of hepatocellular carcinoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
