Primary Identifier | MGI:2140475 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 100317 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including flagellated sperm motility; proacrosomal vesicle fusion; and receptor-mediated endocytosis of virus by host cell. Located in trans-Golgi network. Is expressed in gut; nasal cavity epithelium; and nervous system. Orthologous to human KIAA0319L (KIAA0319 like). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male infertility associated with oligozoospermia, immotile sperm, coiled sperm tails with mitochondrial disorganization, impaired acrosome formation, and globozoospermia. [provided by MGI curators] |