Primary Identifier | MGI:1918764 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 71514 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-templated transcription; and negative regulation of circadian rhythm. Acts upstream of or within DNA damage response; chromosome organization; and positive regulation of sister chromatid cohesion. Located in paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich). PHENOTYPE: Mice homozygous for a null allele die embryonically. Heterozygous gene trap mice show abnormality in entrainment of circadian rhythm. [provided by MGI curators] |