| Primary Identifier | MGI:1917614 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 384061 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hormone activity. Involved in positive regulation of brown fat cell differentiation and response to muscle activity. Located in endoplasmic reticulum; extracellular region; and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; limb; and musculature. Orthologous to human FNDC5 (fibronectin type III domain containing 5). PHENOTYPE: Mice homozygous for a knock-out mice exhibit increased trabecular bone mass and bone connectivity density with resistance to ovariectomy-induced osteoporosis. Homozygous KO also increases susceptibility to diet-induced obesity, hepatic steatosis, cardiac hypertrophy and cardiac inflammation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
