| Primary Identifier | MGI:2651811 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 216343 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables tryptophan 5-monooxygenase activity. Predicted to be involved in aromatic amino acid metabolic process and serotonin biosynthetic process. Predicted to act upstream of or within obsolete serotonin biosynthetic process from L-tryptophan. Located in neuron projection. Is expressed in several structures, including 2-cell stage conceptus; germ cell of ovary; nervous system; retina; and tongue. Used to study melancholic depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; anxiety disorder (multiple); autistic disorder; and drug dependence (multiple). Orthologous to human TPH2 (tryptophan hydroxylase 2). PHENOTYPE: Mutations in this locus result in abnormal serotonin levels in the brain. Whether an increase or decrease in serotonin levels is seen depends on the specific nucleotide substitution/point mutation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
