| Primary Identifier | MGI:97809 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 19263 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables protein tyrosine phosphatase activity. Involved in angiogenesis and dephosphorylation. Predicted to be located in membrane. Predicted to be part of signaling receptor complex. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; genitourinary system; and umbilical artery. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). PHENOTYPE: Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
