| Primary Identifier | MGI:95476 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 14077 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytoskeletal protein binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including cholesterol homeostasis; phospholipid homeostasis; and positive regulation of long-chain fatty acid import into cell. Acts upstream of or within brown fat cell differentiation and regulation of phosphatidylcholine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in hypertension and type 2 diabetes mellitus. Orthologous to human FABP3 (fatty acid binding protein 3). PHENOTYPE: Inactivation of this locus results in impaired fatty acid utilization. Homozygous null mice show exercise intolerance and cardiac hypertrophy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
