| Primary Identifier | MGI:2651874 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230784 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables GDP-dissociation inhibitor activity and PH domain binding activity. Involved in several processes, including DNA damage response, signal transduction by p53 class mediator; negative regulation of TORC1 signaling; and negative regulation of translation in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including D-glucose import; positive regulation of metabolic process; and regulation of intracellular signal transduction. Part of TORC2 complex and nucleotide-activated protein kinase complex. Is expressed in central nervous system; heart; and retina. Orthologous to human SESN2 (sestrin 2). PHENOTYPE: Mouse lung fibroblasts homozgyous for a gene trap allele exhibit increased cellular sensitivity to hydrogen peroxide, decreased proliferation, and increased apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
