| Primary Identifier | MGI:2685877 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 381560 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables phospholipid scramblase activity. Involved in apoptotic cell clearance; phosphatidylserine exposure on apoptotic cell surface; and positive regulation of myoblast differentiation. Acts upstream of or within establishment of localization in cell and tolerance induction to self antigen. Is active in plasma membrane. Orthologous to human XKR8 (XK related 8). PHENOTYPE: Mice homozygous for a null allele exhibit decreased testis weight, oligozoospermia, abnormal seminiferous tubule and cauda epididymis morphology, large vacuoles in Sertoli cells, and male infertility caused by inefficient apoptotic testicular germ cell clearance. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
