Primary Identifier | MGI:2140494 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 100336 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein phosphatase regulator activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nuclear speck. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; adrenal gland; and brain. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). PHENOTYPE: Embryos homozygous for knock-out allele exhibit severe growth retardation and impaired cell proliferation and die between embryonic days 6.5 and 7.5. [provided by MGI curators] |