| Primary Identifier | MGI:88357 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 12567 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to ionomycin; cellular response to lipopolysaccharide; and cellular response to phorbol 13-acetate 12-myristate. Located in bicellular tight junction and nucleus. Part of cyclin D2-CDK4 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Orthologous to human CDK4 (cyclin dependent kinase 4). PHENOTYPE: Homozygous null mutants have small size, insulin-deficient diabetes, sterility in females; near-sterility in males and impaired prolactin secretion due to hypoplastic pituitary development. Locomotor and endocrine gland defects are seen with some alleles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
