| Primary Identifier | MGI:1098641 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 242687 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable Arp2/3 complex binding activity; SH3 domain binding activity; and protein kinase A regulatory subunit binding activity. Involved in postsynaptic actin cytoskeleton organization. Acts upstream of or within several processes, including Rac protein signal transduction; lamellipodium organization; and megakaryocyte development. Located in several cellular components, including early endosome; lamellipodium; and ruffle. Part of SCAR complex. Is active in synapse. Is expressed in several structures, including central nervous system; dorsal aorta; genitourinary system; heart; and yolk sac. Orthologous to human WASF2 (WASP family member 2). PHENOTYPE: Homozygous mutants show impaired embryonic development and do not survive to term. In addition to reduced embryo size, observed defects include hemorrhaging, abnormal somite development, perturbed angiogenesis, and shrunken cerebral ventricles. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
