| Primary Identifier | MGI:2685541 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 230796 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables enzyme inhibitor activity; histone binding activity; and histone deacetylase binding activity. Acts upstream of or within several processes, including cellular response to insulin stimulus; glucose metabolic process; and negative regulation of biosynthetic process. Located in cytosol and nucleus. Is expressed in cerebral cortex; heart ventricle; lung; and pancreas. Orthologous to human WDTC1 (WD and tetratricopeptide repeats 1). PHENOTYPE: Mice heterozygous for a gene trapped allele are obese and insulin resistant with significantly elevated plasma insulin and leptin levels. Although a number of adult homozygotes are also described as obese, the majority of homozygotes die in utero thus precluding statistically significant analyses. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
