| Primary Identifier | MGI:96828 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 16971 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of signal transduction; positive regulation of cholesterol transport; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and transforming growth factor beta receptor signaling pathway. Located in plasma membrane. Is active in several cellular components, including external side of plasma membrane; focal adhesion; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
