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Protein Coding Gene : Clic4 chloride intracellular channel 4
Primary Identifier  MGI:1352754 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  29876
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Predicted to enable chloride channel activity. Involved in keratinocyte differentiation. Acts upstream of or within several processes, including endothelial cell morphogenesis; vacuolar acidification; and vasculature development. Located in mitochondrion. Is expressed in brain; metanephros; skin; and spleen. Orthologous to human CLIC4 (chloride intracellular channel 4).
PHENOTYPE: Mice homozygous for null mutations may display decreased survival, body weight and female fertility, impaired angiogenesis, increased suscpetibility to Listeria infection, increased resistance to LPS treatment, skin erosions and/or delayed wound healing. [provided by MGI curators]
  • synonyms:
  • MGI:1206574,
  • D0Jmb3,
  • mtCLIC,
  • chloride intracellular channel 4,
  • mc3s5,
  • DNA segment, Jeremy M. Boss 3,
  • Clic4
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3 Involved In Mutations

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Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Disease

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