| Primary Identifier | MGI:103039 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 20847 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 9.1.0) Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and type I interferon-mediated signaling pathway. Located in cytoplasm and nucleus. Is expressed in several structures, including 2-cell stage conceptus; 4-8 cell stage conceptus; blastocyst-stage conceptus; central nervous system; and genitourinary system. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). PHENOTYPE: Immune response is impaired in homozygous null mice. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
