Primary Identifier | MGI:106512 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 52830 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in P-body and nucleus. Is expressed in several structures, including brain ventricular layer; genitourinary system; retina; and thymus primordium. Orthologous to human PNRC2 (proline rich nuclear receptor coactivator 2). PHENOTYPE: Mice homozygous for a null allele exhibit decreased body weight, decreased percent body fat, resistance to diet-induced obesity, increased energy expenditure and increase heat production. [provided by MGI curators] |