| Primary Identifier | MGI:96398 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 15903 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables several functions, including bHLH transcription factor binding activity; leptomycin B binding activity; and transcription regulator inhibitor activity. Involved in several processes, including negative regulation of myoblast differentiation; notochord development; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to leptomycin B; negative regulation of macromolecule biosynthetic process; and negative regulation of osteoblast differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; metanephros; and sensory organ. Used to study Sjogren's syndrome. Orthologous to human ID3 (inhibitor of DNA binding 3). PHENOTYPE: Homozygotes for a targeted null mutation exhibit compromised humoral immunity. Homozygotes for knockout alleles of both Id1 and Id3 die by embryonic day 13.5 with vascular malformations of the forebrain. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
