| Primary Identifier | MGI:1891692 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 74326 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA destabilization. Located in nucleus. Is expressed in central nervous system; jaw; limb; sensory organ; and thymus. Orthologous to human HNRNPR (heterogeneous nuclear ribonucleoprotein R). PHENOTYPE: Mice homozygous for a knock-out allele in which expression of the full-length isoform is abolished while expression of the N-terminally truncated isoform is retained are viable and survive to adulthood with no overt phenotypic defects. In culture, primary motoneurons from these mice do not exhibit axonal growth defects but show increased accumulation of double strand breaks and an impaired DNA damage response upon exposure to genotoxic agents. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
