| Primary Identifier | MGI:104591 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 17965 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables BMP binding activity and morphogen activity. Involved in several processes, including determination of dorsal identity; negative regulation of monocyte chemotaxis; and sequestering of BMP in extracellular matrix. Acts upstream of or within negative regulation of BMP signaling pathway; neuron projection morphogenesis; and positive regulation of neuron differentiation. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain ventricular layer; embryo mesenchyme; limb; and nose. Orthologous to human MICOS10-NBL1 (MICOS10-NBL1 readthrough) and NBL1 (NBL1, DAN family BMP antagonist). PHENOTYPE: Mice homozygous for disruptions in this gene appear to have a normal nervous system, although one allele exhibits reduced sensitivity to pain during inflammation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
