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Protein Coding Gene : Igsf21 immunoglobulin superfamily, member 21
Primary Identifier  MGI:2681842 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  230868
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Involved in synapse maturation and trans-synaptic signaling, modulating synaptic transmission. Located in external side of plasma membrane; inhibitory synapse; and presynaptic membrane. Is active in postsynaptic density membrane. Is expressed in several structures, including brain; ganglia; genitourinary system; hemolymphoid system gland; and retina. Orthologous to human IGSF21 (immunoglobin superfamily member 21).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal differentiation of inhibitory synapses with decreased mIPSC frequency and prepulse inhibition. [provided by MGI curators]
  • synonyms:
  • MGI:2684987,
  • Igsf21,
  • gene model 141, (NCBI),
  • MGC:67646,
  • BC055811,
  • LOC230868,
  • cDNA sequence BC055811,
  • immunoglobulin superfamily, member 21,
  • Gm141
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