Primary Identifier | MGI:2655198 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 242726 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable identical protein binding activity and protein-arginine deiminase activity. Involved in embryonic cleavage. Acts upstream of or within several processes, including cytoplasm organization; in utero embryonic development; and regulation of translation by machinery localization. Located in cortical granule and intermediate filament cytoskeleton. Is expressed in early embryo; ileum; and reproductive system. Orthologous to human PADI6 (peptidyl arginine deiminase 6). PHENOTYPE: Mice homozygous for a null allele exhibit altered oocyte cytoplasmic structures that lead to a failure of zygotes to progress beyond the 2 cell stage and female infertility. [provided by MGI curators] |