| Primary Identifier | MGI:95278 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 13836 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable growth factor binding activity; molecular function activator activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including lens fiber cell morphogenesis; mammary gland epithelium development; and osteoclast differentiation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2). PHENOTYPE: Mice homozygous for a null allele exhibit abnormal angiogenesis. Mice homozygous for a gene trap allele exhibit increased incidence of chemically-induced tumors, increased metastatic potential, and age-related cataracts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
