| Primary Identifier | MGI:1277950 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 12371 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables cysteine-type endopeptidase activity. Involved in cellular response to dexamethasone stimulus. Acts upstream of or within several processes, including fibroblast apoptotic process; positive regulation of cysteine-type endopeptidase activity; and positive regulation of neuron apoptotic process. Located in cytosol and nucleus. Is expressed in several structures, including brain; early embryo; forelimb interdigital region; hemolymphoid system gland; and neural ectoderm. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (caspase 9). PHENOTYPE: Homozygous targeted mutants die perinatally with enlarged and malformed cerebrums caused by reduced apoptosis during brain development. Broad system- and stimulus-dependent effects are seen on apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
