| Primary Identifier | MGI:99908 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 21941 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protease binding activity. Predicted to be involved in positive regulation of TRAIL production; positive regulation of apoptotic process; and positive regulation of tumor necrosis factor production. Predicted to be located in nucleoplasm and plasma membrane. Is expressed in several structures, including adrenal gland; brain; intestine; reproductive system; and thymus. Orthologous to human TNFRSF8 (TNF receptor superfamily member 8). PHENOTYPE: Mice homozygous for a knock-out allele display an enlarged thymus, impaired activation-induced death of double-positive thymocytes after CD3 cross-linking, and decreased susceptibility to graft versus host disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
