| Primary Identifier | MGI:97368 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 18158 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hormone activity and hormone receptor binding activity. Involved in several processes, including MAPK cascade; coronary vasculature development; and endothelial cell proliferation. Acts upstream of or within cardiac muscle hypertrophy in response to stress. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and extracellular space. Is expressed in heart; heart atrium; heart left ventricle; heart ventricle; and primitive ventricle. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). PHENOTYPE: Homozygotes for a targeted null mutation develop multifocal fibrotic ventricular lesions which become larger and more numerous under conditions of ventricular pressure overload. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
