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Protein Coding Gene : Exosc10 exosome component 10

Primary Identifier  MGI:1355322 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  50912
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of euchromatin; nuclear exosome (RNase complex); and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Orthologous to human EXOSC10 (exosome component 10).
PHENOTYPE: Mice homozygous for a null allele exhibit reduced female fertility with defective GVBD and endomembrane components. [provided by MGI curators]
  • synonyms:
  • polymyositis/scleroderma autoantigen 2,
  • Pmscl2,
  • p2,
  • PM/Scl-100,
  • Exosc10,
  • p4,
  • p3,
  • RRP6,
  • exosome component 10,
  • PM-Scl

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

1 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

4 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For