Primary Identifier | MGI:1355322 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 50912 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable 3'-5'-RNA exonuclease activity and single-stranded RNA binding activity. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of euchromatin; nuclear exosome (RNase complex); and small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including cerebral cortex; gonad; liver; metanephros; and muscle tissue. Orthologous to human EXOSC10 (exosome component 10). PHENOTYPE: Mice homozygous for a null allele exhibit reduced female fertility with defective GVBD and endomembrane components. [provided by MGI curators] |