| Primary Identifier | MGI:98310 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 20481 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity; histone deacetylase inhibitor activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase III. Acts upstream of or within several processes, including camera-type eye development; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription repressor complex. Is expressed in cornea; embryo; eye; forelimb bud; and forelimb interdigital region. Orthologous to human SKI (SKI proto-oncogene). PHENOTYPE: Homozygous null embryos die during late gestation and exhibit neural tube defects, craniofacial anomalies, and reduced skeletal muscle mass. Haploinsufficient mice have an increased susceptibility to tumorigenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
