| Primary Identifier | MGI:95622 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 14403 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in chemical synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Located in axon; dendrite; and neuronal cell body. Is active in GABA-ergic synapse and postsynaptic membrane. Is expressed in several structures, including brain; metanephros; respiratory system; sensory organ; and ventricular layer. Used to study postpartum depression. Human ortholog(s) of this gene implicated in idiopathic generalized epilepsy 10. Orthologous to human GABRD (gamma-aminobutyric acid type A receptor subunit delta). PHENOTYPE: Mice homozygous for a null allele exhibit increased postpartum depression and anxiety behaviors, lethality of pups due to materal neglect, and increased cued and contextual conditional freezing. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
