Primary Identifier | MGI:2387630 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 231002 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phospholipid binding activity. Involved in 3'-UTR-mediated mRNA destabilization. Located in mitochondrion. Orthologous to human PLEKHN1 (pleckstrin homology domain containing N1). PHENOTYPE: Older male mice homozygous for a knock-out allele develop obesity associated with increased epididymal fat pad and liver weight, hyperphagia and increased circulating leptin levels. [provided by MGI curators] |