| Primary Identifier | MGI:1277162 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12571 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables kinase activity. Involved in hemopoiesis. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of hematopoietic stem cell differentiation. Part of cyclin D2-CDK6 complex. Is expressed in several structures, including alimentary system; central nervous system; forelimb bud; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in high grade glioma; lung non-small cell carcinoma; pancreatic adenocarcinoma; pancreatic ductal carcinoma; and primary autosomal recessive microcephaly 12. Orthologous to human CDK6 (cyclin dependent kinase 6). PHENOTYPE: Mice homozygous for disruptions in this gene display hematopoietic abnormalities affecting spleen and thymus size. Female body weight and fertility are also reduced. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
