Primary Identifier | MGI:1351340 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 108069 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium channel regulator activity and group II metabotropic glutamate receptor activity. Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within gene expression. Located in several cellular components, including axon; dendritic spine; and postsynaptic density. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and visual system. Orthologous to human GRM3 (glutamate metabotropic receptor 3). PHENOTYPE: Mice homozygous for a targeted mutation display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a knock-out allele exhibit altered neuroprotection. [provided by MGI curators] |