| Primary Identifier | MGI:96079 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 15234 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable chemoattractant activity; growth factor activity; and identical protein binding activity. Acts upstream of or within several processes, including hepatocyte growth factor receptor signaling pathway; regulation of MAPK cascade; and regulation of macromolecule metabolic process. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; egg cylinder; embryo mesenchyme; and genitourinary system. Used to study autosomal recessive nonsyndromic deafness 39 and breast cancer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor). PHENOTYPE: Homozygotes for targeted null mutations exhibit reduced embryonic livers, impaired migration of dermomyotome precursors affecting skeletal muscle formation, defective navigation of hypoglossal motor axons, abnormal placentas, and prenatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
