Primary Identifier | MGI:2140885 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 242864 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in several processes, including N-acylphosphatidylethanolamine metabolic process; host-mediated regulation of intestinal microbiota composition; and positive regulation of brown fat cell differentiation. Acts upstream of or within N-acylethanolamine metabolic process. Is active in hippocampal mossy fiber to CA3 synapse; smooth endoplasmic reticulum membrane; and synaptic membrane. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). PHENOTYPE: Mice homozygous for a null mutation are viable and healthy, but have abnormal brain levels of N-acyl ethanolamines and N-acyl phosphatidylethanolamines. [provided by MGI curators] |