Primary Identifier | MGI:1923764 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 64295 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to be involved in ERAD pathway. Predicted to be located in several cellular components, including centrosome; postsynaptic membrane; and recycling endosome. Orthologous to human TMUB1 (transmembrane and ubiquitin like domain containing 1). PHENOTYPE: Mice homozygous for a null allele show nocturnal hyperactivity, decreased REM and NREM sleep time during dark phase, reduced total body and abdominal fat, and increased monocyte count. Mice homozygous for a different null allele are resistant to etoposide-induced apoptosis. [provided by MGI curators] |