| Primary Identifier | MGI:1927345 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 57434 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ATP binding activity and ATP-dependent DNA damage sensor activity. Predicted to contribute to four-way junction DNA binding activity. Acts upstream of or within several processes, including chordate embryonic development; regulation of apoptotic process; and response to X-ray. Predicted to be located in nucleoplasm. Predicted to be part of Rad51B-Rad51C-Rad51D-XRCC2 complex. Predicted to be active in centrosome and replication fork. Is expressed in embryo. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group U; pancreatic cancer; primary ovarian insufficiency 17; and spermatogenic failure 50. Orthologous to human XRCC2 (X-ray repair cross complementing 2). PHENOTYPE: Homozygotes for a targeted null mutation exhibit chromosomal instability, excess neuronal apoptosis, and lethality ranging from midgestation through birth. Neonates die from respiratory failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
