| Primary Identifier | MGI:2441745 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231093 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables metallocarboxypeptidase activity and tubulin binding activity. Involved in defense response to virus and protein deglutamylation. Located in cytosol and nucleus. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Human ortholog(s) of this gene implicated in retinitis pigmentosa 75. Orthologous to human AGBL5 (AGBL carboxypeptidase 5). PHENOTYPE: Homozygotes for a knock-out allele show increased susceptibility to infection with DNA viruses. Homozygotes for a different knock-out allele show defects in multiple steps of spermatogenesis leading to manchette malformation, supernumerary centrioles, defective sperm axonemes, and male infertility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
