Primary Identifier | MGI:1276123 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 22226 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable corticotropin-releasing hormone receptor 1 binding activity; corticotropin-releasing hormone receptor 2 binding activity; and histone deacetylase inhibitor activity. Involved in positive regulation of transcription by RNA polymerase II; response to auditory stimulus; and startle response. Predicted to be located in axon; dendrite; and perikaryon. Is expressed in brain. Orthologous to human UCN (urocortin). PHENOTYPE: Homozygous null mutant mice exhibit impaired hearing and reduced acoustic startle response associated with a reduction in outer hair cell length. In addition, some mutant mice exhibit elevated anxiety-like behaviors. [provided by MGI curators] |