| Primary Identifier | MGI:1096345 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 231103 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables kinase inhibitor activity. Acts upstream of or within intracellular glucose homeostasis; negative regulation of glucokinase activity; and protein import into nucleus. Located in nucleus. Is expressed in diencephalon lateral wall mantle layer; liver left lobe; liver right lobe; midbrain mantle layer; and retina. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator). PHENOTYPE: Homozygous inactivation of this gene leads to reduced glucokinase protein levels and activity in the liver and altered glucose homeostasis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
