| Primary Identifier | MGI:107678 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 20537 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables D-glucose:sodium symporter activity. Involved in intestinal D-glucose absorption; regulation of transporter activity; and renal D-glucose absorption. Acts upstream of or within D-glucose transmembrane transport; intestinal absorption; and metanephros development. Located in apical plasma membrane and brush border. Is expressed in alimentary system; brain; and urinary system. Human ortholog(s) of this gene implicated in glucose-galactose malabsorption. Orthologous to human SLC5A1 (solute carrier family 5 member 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
