Primary Identifier | MGI:1891748 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 59003 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables actin binding activity. Acts upstream of or within cytoskeleton organization and enucleate erythrocyte development. Located in actin cytoskeleton. Orthologous to human MAEA (macrophage erythroblast attacher, E3 ubiquitin ligase). PHENOTYPE: Mice homozygous for a gene trapped allele die perinatally displaying reduced fetal size, pallor, reduced numbers of erythroblastic islands, defects in terminal erythroid maturation, and severely impaired terminal differentiation of fetal liver macrophages. [provided by MGI curators] |