| Primary Identifier | MGI:1932557 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 56384 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in brain; embryo; gonad; liver; and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). PHENOTYPE: Homozygous deletion of this gene causes embryonic lethality prior to E6.5 while ~50% of heterozygotes die before E13.5. Surviving heterozygous mice show altered glucose metabolism, impaired control of brain ATP levels, and increased susceptibility to kainic acid-induced seizures. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
