Primary Identifier | MGI:2686519 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 381633 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables mRNA 3'-UTR binding activity and transferrin receptor binding activity. Involved in 3'-UTR-mediated mRNA stabilization and spermatogenesis. Located in extracellular space and perinuclear region of cytoplasm. Orthologous to human NICOL1 (NELL2 interacting cell ontogeny regulator 1). PHENOTYPE: Mice homozygous for a null allele exhibit male infertility with epididymis degeneration, impaired sperm migration in female genital tract, impaired binding of sperm to zona pellucida, and decreased fertilization frequency. [provided by MGI curators] |