| Primary Identifier | MGI:2152883 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 242960 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable iron ion binding activity. Acts upstream of or within multicellular organismal-level iron ion homeostasis and positive regulation of protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality before turning of the embryo with iron overload, growth retardation, and hemorrhage. Mice heterozygous for a knock-out allele exhibit abnormal iron homeostasis when fed a low iron diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
