| Primary Identifier | MGI:105370 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 12182 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable NAD+ nucleotidase, cyclic ADP-ribose generating and phosphorus-oxygen lyase activity. Predicted to be involved in several processes, including positive regulation of B cell proliferation; regulation of calcium-mediated signaling; and regulation of neutrophil chemotaxis. Predicted to be located in uropod. Predicted to be active in plasma membrane. Is expressed in cerebellum; forebrain; and spleen white pulp. Orthologous to human BST1 (bone marrow stromal cell antigen 1). PHENOTYPE: Homozygous null mice show delayed peritoneal B-1 cell development and a rise in CD38low/- B-lineage cells in bone marrow and spleen. The systemic thymus-independent-2 antigen-induced IgG3 and mucosal thymus-dependent antigen-elicited IgA responses are selectively impaired. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
