| Primary Identifier | MGI:2151156 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 116873 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable calcium channel regulator activity; calcium ion binding activity; and store-operated calcium channel activity. Predicted to be involved in activation of store-operated calcium channel activity; intracellular calcium ion homeostasis; and store-operated calcium entry. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including adipose tissue; cardiovascular system; central nervous system; endocrine gland; and male reproductive gland or organ. Orthologous to human STIM2 (stromal interaction molecule 2). PHENOTYPE: Mice homozygous for a null allele exhibit a slight growth delay and premature death while embryonic fibroblasts show reduced store-operated Ca2+ influx. Mice homozygous for a different null allele show increased neuron survival under hypoxic conditions and resistance to ischemic brain injury. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
